NC Lineberger member William Y. Kim, MD, and his colleagues report in the journal Nature Communications they have created mouse models of both papillary and clear cell renal cell carcinoma that faithfully mimic the genetic changes seen in tumors of patients with these cancers.
University of North Carolina Lineberger Comprehensive Cancer Center scientists have developed preclinical laboratory models of the two most common types of kidney cancer, an advancement that may aid in the evaluation of novel immunotherapy combinations and targets.
William Y. Kim, MD, a UNC Lineberger member and associate professor in the UNC School of Medicine, and his colleagues report in the journal Nature Communications they have created mouse models of both papillary and clear cell renal cell carcinoma that faithfully mimic the genetic changes seen in tumors of patients with these cancers. The researchers envision using the models to study new potential treatments, including possible immunotherapy approaches.
“Having faithful genetic models of kidney cancer will enable us to develop a better understanding of the biology behind these cancers,” said Kim. “We also can use these models to look for new targets and validate them in the preclinical setting more quickly as well as to test possible novel treatments that, if they work well, could be considered for patients with these genomic alterations.”
3 years ago, 150 Supporters of Kure It Cancer Research gathered aboard Pacific Avalon's 128' yacht, Ambassador, on Thursday, July 17th for a bay cruise in Newport Beach, California. Sponsored by Extra Space Storage and in partnership with the California Self Storage Association (CSSA), the charity casino cruise was the perfect ending to a wonderful 2014 CSSA Owner's Summit. With all cruise proceeds directly supporting underfunded cancer research, the spirit of generosity and fun took hold and before we knew it, Open Tech Alliance's President & CEO, Robert Chiti, was jumping off the bow of the boat to earn a $10,000 donation to Kure It.